Senomyx, Inc.

(Name of Issuer)

Common Stock, $0.001 par value

(Title of Class of Securities)

81724Q107

(CUSIP Number)

February 7, 2014

(Date of Event Which Requires Filing of this Statement)

*	The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

CUSIP No.		81724Q107
1.	NAME OF REPORTING PERSONS
	I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
	RIMA Senvest Management, LLC
2.	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
				(a)  [_]
				(b)  [X]
3.	SEC USE ONLY
4.	CITIZENSHIP OR PLACE OF ORGANIZATION
	Delaware
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
5.	SOLE VOTING POWER
	0
6.	SHARED VOTING POWER
	5,818,657
7.	SOLE DISPOSITIVE POWER
	0
8.	SHARED DISPOSITIVE POWER
	5,818,657
9.	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
	5,818,657
10.	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)			[_]
11.	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
	14.27%
12.	TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
	OO, IA

CUSIP No.		81724Q107
1.	NAME OF REPORTING PERSONS
	I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
	Richard Mashaal
2.	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
				(a)  [_]
				(b)  [X]
3.	SEC USE ONLY
4.	CITIZENSHIP OR PLACE OF ORGANIZATION
	Canada
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
5.	SOLE VOTING POWER
	0
6.	SHARED VOTING POWER
	5,818,657
7.	SOLE DISPOSITIVE POWER
	0
8.	SHARED DISPOSITIVE POWER
	5,818,657
9.	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
	5,818,657
10.	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)			[_]
11.	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
	14.27%
12.	TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
	IN, HC

CUSIP No.		81724Q107
1.	NAME OF REPORTING PERSONS
	I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
	Senvest Master Fund, L.P.
2.	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
				(a)  [_]
				(b)  [X]
3.	SEC USE ONLY
4.	CITIZENSHIP OR PLACE OF ORGANIZATION
	Cayman Islands
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
5.	SOLE VOTING POWER
	0
6.	SHARED VOTING POWER
	3,752,970
7.	SOLE DISPOSITIVE POWER
	0
8.	SHARED DISPOSITIVE POWER
	3,752,970
9.	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
	3,752,970
10.	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)			[_]
11.	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
	9.20%
12.	TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
	PN

CUSIP No.		81724Q107
1.	NAME OF REPORTING PERSONS
	I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
	Senvest International L.L.C.
2.	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
				(a)  [_]
				(b)  [X]
3.	SEC USE ONLY
4.	CITIZENSHIP OR PLACE OF ORGANIZATION
	Delaware
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH
5.	SOLE VOTING POWER
	0
6.	SHARED VOTING POWER
	2,065,417
7.	SOLE DISPOSITIVE POWER
	0
8.	SHARED DISPOSITIVE POWER
	2,065,417
9.	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
	2,065,417
10.	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)			[_]
11.	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
	5.06%
12.	TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
	BD

 

CUSIP No.

81724Q107

Item 1.	(a).	Name of Issuer:
		Senomyx, Inc.

	(b).	Address of issuer's principal executive offices:
		4767 Nexus Centre Drive San Diego, California 92121

Item 2.	(a).	Name of person filing:
		RIMA Senvest Management, LLC Richard Mashaal Senvest Master Fund, L.P. Senvest International L.L.C.

	(b).	Address or principal business office or, if none, residence:
		RIMA Senvest Management, LLC 110 East 55th Street Suite 1600 New York, New York 10022   Richard Mashaal c/o RIMA Senvest Management, LLC 110 East 55th Street Suite 1600 New York, New York 10022   Senvest Master Fund, L.P. Gardenia Court, Suite 3307 45 Market Street, Camana Bay Grand Cayman KY1-1103 Cayman Islands   Senvest International L.L.C. 110 East 55th Street Suite 1600 New York, New York 10022

	(c).	Citizenship:
		RIMA Senvest Management, LLC – Delaware Richard Mashaal – Canada Senvest Master Fund, L.P. – Cayman Islands Senvest International L.L.C. – Delaware

	(d).	Title of class of securities:

Common Stock, $0.001 par value

 

 

 

	(e).	CUSIP No.:
		81724Q107

Item 3.

If This Statement is filed pursuant to §§.240.13d-1(b) or 240.13d-2(b), or (c), check whether the person filing is a

(a)

[_]

Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o).

(b)

[_]

Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).

(c)

[_]

Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c).

(d)

[_]

Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8).

(e)

[_]

An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);

(f)

[_]

An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);

(g)

[_]

A parent holding company or control person in accordance with §240.13d-1(b)(1)(ii)(G);

(h)

[_]

A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C.1813);

(i)

[_]

A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);

(j)

[_]

A non-U.S. institution in accordance with §240.13d-1(b)(1)(ii)(J);

 

Item 4.

Ownership.

Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.

	(a)	Amount beneficially owned:
		RIMA Senvest Management, LLC - 5,818,657 Richard Mashaal – 5,818,657 Senvest Master Fund, L.P. – 3,752,970 Senvest International L.L.C. – 2,065,417

	(b)	Percent of class:
		RIMA Senvest Management, LLC – 14.27% Richard Mashaal – 14.27% Senvest Master Fund, L.P. – 9.20% Senvest International L.L.C. – 5.06

	(c)	Number of shares as to which the person has:
		RIMA Senvest Management, LLC
		(i)	Sole power to vote or to direct the vote	0	,
		(ii)	Shared power to vote or to direct the vote	5,818,657	,
		(iii)	Sole power to dispose or to direct the disposition of	0	,
		(iv)	Shared power to dispose or to direct the disposition of	5,818,657	.
		Richard Mashaal:

		(i)	Sole power to vote or to direct the vote	0	,
		(ii)	Shared power to vote or to direct the vote	5,818,657	,
		(iii)	Sole power to dispose or to direct the disposition of	0	,
		(iv)	Shared power to dispose or to direct the disposition of	5,818,657	.

Senvest Master Fund, L.P.:

		(i)	Sole power to vote or to direct the vote	0	,
		(ii)	Shared power to vote or to direct the vote	3,752,970	,
		(iii)	Sole power to dispose or to direct the disposition of	0	,
		(iv)	Shared power to dispose or to direct the disposition of	3,752,970	.

Senvest International L.L.C.:

		(i)	Sole power to vote or to direct the vote	0	,
		(ii)	Shared power to vote or to direct the vote	2,065,417	,
		(iii)	Sole power to dispose or to direct the disposition of	0	,
		(iv)	Shared power to dispose or to direct the disposition of	2,065,417	.

	Instruction:  For computations regarding securities which represent a right to acquire an underlying security see §240.13d-3(d)(1).
Item 5.	Ownership of Five Percent or Less of a Class.

	If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following [_].
	Not applicable

Item 6.

Ownership of More Than Five Percent on Behalf of Another Person.

	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified.  A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required.
	Not applicable

Item 7.

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.

	If a parent holding company or control person has filed this schedule, pursuant to Rule 13d-1(b)(1)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary.  If a parent holding company or control person has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary.
	Not applicable

Item 8.

Identification and Classification of Members of the Group.

	If a group has filed this schedule pursuant to §240.13d-1(b)(1)(ii)(J), so indicate under Item 3(j) and attach an exhibit stating the identity and Item 3 classification of each member of the group.  If a group has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identity of each member of the group.
	Not applicable

Item 9.

Notice of Dissolution of Group.

	Notice of dissolution of a group may be furnished as an exhibit stating the date of the dissolution and that all further filings with respect to transactions in the security reported on will be filed, if required, by members of the group, in their individual capacity.  See Item 5.
	Not applicable

Item 10.

Certification.

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

		February 10, 2014
		(Date)
	RIMA SENVEST MANAGEMENT, LLC
	By:	/s/ George Malikotsis
		George Malikotsis
		Vice President
	RICHARD MASHAAL
	By:	/s/ Richard Mashaal
		(Signature)

	SENVEST MASTER FUND, L.P. By: RIMA Senvest Management, LLC, its general partner
	By:	/s/ George Malikotsis
		George Malikotsis Vice President

	SENVEST INTERNATIONAL, L.L.C.
	By:	/s/ George Malikotsis
		George Malikotsis
		Vice President

*	The Reporting Persons disclaim beneficial ownership in the shares reported herein except to the extent of their pecuniary interest therein.

Dated:  February 10, 2014	RIMA SENVEST MANAGEMENT, LLC
	By:	/s/ George Malikotsis
		George Malikotsis
		Vice President
	RICHARD MASHAAL
	By:	/s/ Richard Mashaal
		(Signature)

	SENVEST MASTER FUND, L.P. By: RIMA Senvest Management, L.L.C., its general partner
	By:	/s/ George Malikotsis
		George Malikotsis Vice President

	SENVEST INTERNATIONAL, L.L.C.
	By:	/s/ George Malikotsis
		George Malikotsis
		Vice President